QUINOXALINE DERIVATIVE

• Main Authors: KAWATE KENJI, NAKANO YOICHI, GOTANDA KOTARO, SHINPO ATSUSHI, SATO HIDEICHIRO, KOBAYASHI HIDEO, OKADA AKIRA
• Format: Patent
• Language: English; Japanese
• Published: 30.10.2014
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide a compound which has an inhibitory effect on PDE9 and is useful as a therapeutic agent for dysuria and the like.SOLUTION: Provided is a quinoxaline derivative represented by formula (I) or a salt thereof. (Rand Rare each independently H or a Calkyl group; Ris a Calkyl group or a Calkenyl group substituted by a carboxylic group or a Calkoxycarbonyl group; R, R, and Rare each H; Rand Rare each independently H, or a Calkyl group or a Calkoxy group which may be substituted by a halogen atom; X is O; and Ato Aare each C.) 【課題】ＰＤＥ９阻害作用を有し、排尿障害等の治療剤として有用な化合物の提供。【解決手段】式（Ｉ）で示されるキノキサリン誘導体又はその塩。（Ｒ1及びＲ2は各々独立にＨ又はＣ1-6アルキル基；Ｒ3はカルボキシ基若しくはＣ1-6アルコキシカルボニル基によって置換されたＣ1-9アルキル基又はＣ2-9アルケニル基；Ｒ4、Ｒ5及びＲ8は各々Ｈ；Ｒ6及びＲ7は各々独立にＨ；場合によりハロゲン原子によって置換されていてもよいＣ1-6アルキル基又はＣ1-6アルコキシ基；ＸはＯ；Ａ1〜Ａ3は各々Ｃ）【選択図】なし