HIGH AFFINITY HIV T CELL RECEPTORS

PROBLEM TO BE SOLVED: To provide T cell receptor having high affinity to HIV.SOLUTION: Provided is TCR having an affinity (K) to SLYNTVATL-HLA-A0201 complex less than or equal to 1 μM and/or an off-rate (k) slower than or equal to 1×10S. The TCR, alone or in combination with a therapeutic agent, tar...

Full description

Saved in:
Bibliographic Details
Main Authors DUNN STEVEN MARK, MOLLOY PETER EAMON, JAKOBSEN BENT KARSTEN, LI YI
Format Patent
LanguageEnglish
Japanese
Published 30.10.2014
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
Online AccessGet full text

Cover

More Information
Summary:PROBLEM TO BE SOLVED: To provide T cell receptor having high affinity to HIV.SOLUTION: Provided is TCR having an affinity (K) to SLYNTVATL-HLA-A0201 complex less than or equal to 1 μM and/or an off-rate (k) slower than or equal to 1×10S. The TCR, alone or in combination with a therapeutic agent, targets HIV infected cells displaying the complex. 【課題】ＨＩＶに高親和性を有するＴ細胞レセプターを提供する。【解決手段】SLYNTVATL−HLA-A*0201複合体に対して、１μMより少ないか等しい親和性(KD)及び/又は１?10-3S-1か若しくはそれより遅い解離速度(koff)を有するTCR。TCRは、単独で又は治療剤との結合で、前記複合体を提示するHIV感染細胞を標的する。【選択図】なし
Bibliography:Application Number: JP20140094723