METHODS AND NUCLEIC ACIDS FOR THE ANALYSIS OF GENE EXPRESSION ASSOCIATED WITH THE DEVELOPMENT OF PROSTATE CELL PROLIFERATIVE DISORDERS

• Main Authors: TETZNER REIMO, SLEDZIEWSKI ANDREW, DISTLER JUERGEN, SHANNON PAYNE, DIETRICH DIMO, MODEL FABIAN, LOFTON-DAY CATHERINE
• Format: Patent
• Language: English; Japanese
• Published: 30.10.2014
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide a method that is for detecting prostate cell proliferative disorders and analyzes gene expression associated with the development of prostate cell proliferative disorders.SOLUTION: The method comprises determining a TFAP2E gene expression level that is one of gene panels of a living body sample separated from a subject of prostate cell proliferative disorders, wherein low expression and/or CpG methylation is a parameter of existence of the disorders. 【課題】前立腺細胞増殖性障害を検出するための、前立腺細胞増殖性障害の発症に関連する遺伝子の発現を解析する方法の提供。【解決手段】前立腺細胞増殖性障害の被験者から単離した生体サンプルの遺伝子パネルの一つであるＴＦＡＰ２Ｅ遺伝子発現レベルを決定することを含み、低発現及び／又はＣｐＧメチル化が該障害の存在の指標となる、方法。【選択図】なし