BIOMARKER DETECTION PROCESS AND ASSAY OF NEUROLOGICAL CONDITION

• Main Authors: KEVIN KA-WANG WANG, RONALD L HAYES, UWE R MUELLER, ZHANG ZHIQUN
• Format: Patent
• Language: English; Japanese
• Published: 23.10.2014
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; TESTING; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide a process and an assay for providing improved measurement of a neurological condition through the quantification of a first biomarker such as GFAP in combination with another biomarker associated with a neurological condition.SOLUTION: The invention provides a robust, quantitative, and reproducible process and assay for diagnosis of a neurological condition in a subject. The invention provides measurement of two or more biomarkers in a biological fluid such as CSF or serum, resulting in a synergistic mechanism for determining the extent of neurological damage in a subject with an abnormal neurological condition and for discerning subtypes thereof or tissue types subjected to damage. 【課題】GFAPなどの第一のバイオマーカーを、神経学的状態と関連した他のバイオマーカーと組合せて定量することを介して、神経学的状態の改善した測定を提供するための方法およびアッセイに対する需要が存在する【解決手段】本発明は、対象の神経学的状態を診断するための、定量的で再現性を有する確固たる方法およびアッセイを提供する。本発明は、生物学的液体、例えばCSFまたは血清中で、2つ以上のバイオマーカーを測定し、異常な神経学的状態を有する対象の神経損傷の程度を測定するための、およびそのサブタイプまたは損傷を被った組織タイプを区別するための相乗的メカニズムを得ることを提供する。【選択図】図１０