IMPROVED DEPOT FORMULATION

PROBLEM TO BE SOLVED: To provide a depot formulation which is a biodegradability control releasing system of a bioactive compound using a biodegradable matrix for medicament delivery.SOLUTION: A formulation comprises: a non-polymeric and water-insoluble high viscous liquid carrier material having a...

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Bibliographic Details
Main Authors WRIGHT JEREMY C, FELIX THEEUWES, STEFANIA SJOBECK, KEITH E BRANHAM, GIBSON JOHN W
Format Patent
LanguageEnglish
Published 09.10.2014
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide a depot formulation which is a biodegradability control releasing system of a bioactive compound using a biodegradable matrix for medicament delivery.SOLUTION: A formulation comprises: a non-polymeric and water-insoluble high viscous liquid carrier material having a viscosity of at least 5,000 cP at 37°C which does not crystallize neat under ambient condition or physiological condition; a certain linear polymer comprising a lactide repeating unit; and one or more solvents having solvent capacity. As a specific example, the formulation comprises sucrose acetate isobutyrate (SAIB), poly(lactide-co-glycolide) (PLGA) and a suitable solvent, preferably NMP (N-methylpyrrolidone), and also as a medicament, risperidone and the like.
Bibliography:Application Number: JP20140095775