COMPOSITION AND METHOD FOR AMPLIFYING HUMAN HEMATOPOIETIC STEM CELL

PROBLEM TO BE SOLVED: To provide a low molecular weight compound or a peptide composition and a method for amplifying a human hematopoietic stem cell.SOLUTION: A composition can efficiently amplify a hematopoietic stem cell under existence and non-existence of SCF (stem cell factor) by adding a low...

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Bibliographic Details
Main Author TODOKORO KAZUO
Format Patent
LanguageEnglish
Published 25.09.2014
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:PROBLEM TO BE SOLVED: To provide a low molecular weight compound or a peptide composition and a method for amplifying a human hematopoietic stem cell.SOLUTION: A composition can efficiently amplify a hematopoietic stem cell under existence and non-existence of SCF (stem cell factor) by adding a low molecular weight compound, such as DOPA and Bryostatin 1 which activates or inhibits an intracellular signaling pathway associated with cell growth, or a peptide of a specific sequence to a culture medium alone or in combination. A producing method of the amplified human hematopoietic stem cell which consists of culturing a human hematopoietic stem cell with a medium added with the composition. A human hematopoietic stem cell culture medium consists of serum-free or human serum culture medium containing the composition.
Bibliography:Application Number: JP20130053001