PROCESS FOR SYNTHESIS OF MOXIFLOXACIN HYDROCHLORIDE
PROBLEM TO BE SOLVED: To provide novel polymorphic forms of moxifloxacin hydrochloride with high product yield and quality, and a simple, safe and cost effective process for producing the polymorphic forms.SOLUTION: Moxifloxacin hydrochloride Form C characterized by having an XRPD with peaks at 15.0...
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Main Authors | , , , , , |
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Format | Patent |
Language | English |
Published |
03.07.2014
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Subjects | |
Online Access | Get full text |
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Summary: | PROBLEM TO BE SOLVED: To provide novel polymorphic forms of moxifloxacin hydrochloride with high product yield and quality, and a simple, safe and cost effective process for producing the polymorphic forms.SOLUTION: Moxifloxacin hydrochloride Form C characterized by having an XRPD with peaks at 15.08, 27.86 and 28.22°2 ±0.2°2 is obtained by: condensing the borate complex of the formula (I) with (S,S)-2,8-diazabicyclo[4.3.0]nonane in an organic solvent to obtain an intermediate (II); hydrolyzing the intermediate (II); and then treating it with methanolic hydrochloric acid. |
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Bibliography: | Application Number: JP20140003579 |