PROCESS FOR SYNTHESIS OF MOXIFLOXACIN HYDROCHLORIDE

PROBLEM TO BE SOLVED: To provide novel polymorphic forms of moxifloxacin hydrochloride with high product yield and quality, and a simple, safe and cost effective process for producing the polymorphic forms.SOLUTION: Moxifloxacin hydrochloride Form C characterized by having an XRPD with peaks at 15.0...

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Main Authors RAJENDRA NARAYANRAO KANKAN, SHASHIREKHA KANATHALA, DHARMARAJ RAMACHANDRA RAO, RAVIKUMAR PUPPALA, MANISH GANGRADE, SRINIVAS LAXMINARAYAN PATHI
Format Patent
LanguageEnglish
Published 03.07.2014
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide novel polymorphic forms of moxifloxacin hydrochloride with high product yield and quality, and a simple, safe and cost effective process for producing the polymorphic forms.SOLUTION: Moxifloxacin hydrochloride Form C characterized by having an XRPD with peaks at 15.08, 27.86 and 28.22°2 ±0.2°2 is obtained by: condensing the borate complex of the formula (I) with (S,S)-2,8-diazabicyclo[4.3.0]nonane in an organic solvent to obtain an intermediate (II); hydrolyzing the intermediate (II); and then treating it with methanolic hydrochloric acid.
Bibliography:Application Number: JP20140003579