CRYSTALLINE FORM OF 3-METHOXY-N-{1-[(2-OXO-1,2,3,4-TETRAHYDROQUINOLINE-7-YL)METHYL]PIPERIDINE-4-YL}BENZAMIDE AND METHOD FOR MANUFACTURING THE SAME

• Main Authors: MATSUSHIMA AYUMU, SHIKANUMA KOSUKE, NOZAWA MASARU, SUZUKI AKIRA, OSAKI NAOHITO
• Format: Patent
• Language: English
• Published: 12.05.2014
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide a crystalline form of 3-methoxy-N-{1-[(2-oxo-1,2,3,4-tetrahydroquinoline-7-yl)methyl]piperidine-4-yl}benzamide stable within a use environment thereof as a medicinal drug and a method for manufacturing the same.SOLUTION: The provided crystal is obtained by dissolving, into a mixed solution of water and ethanol, crystallizing, and drying 3-methoxy-N-{1-[(2-oxo-1,2,3,4-tetrahydroquinoline-7-yl)methyl]piperidine-4-yl}benzamide and has at least one of the following physical properties of (a) through (c): (a) having peaks at 2 =14.5 degrees, 16.3 degrees, 16.7 degrees, and 20.5 degrees on the powder X-ray diffractogram (Cu-Kα) thereof; (b) having a melting point of 197 to 202°C; and (c) having characteristic bands at 687 cm, 1053 cm, 1337 cm, 1541 cm, and 1670 cmon the infrared absorption spectrum thereof.