CRYSTAL FORM OF DIMETHOXY DOCETAXEL AND ITS MANUFACTURING METHOD

PROBLEM TO BE SOLVED: To provide a novel crystal form of dimethoxy docetaxel or 4-acetoxy-2α-benzoyloxy-5 ,20-epoxy-1-hydroxy-7 ,10 -dimethoxy-9-oxotaxa-11-en-13α-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenyl propinate (compound A), and to provide its manufacturing method.SOLUTION: There...

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Main Authors ZASKE LIONEL, DUFRAIGNE MARIELLE, ALEXANDRE GIULIANI, PASCAL BILLOT, MANGIN FABRICE, ELMALEH HAGIT, PATRICIA NORTAIS
Format Patent
LanguageEnglish
Published 24.04.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide a novel crystal form of dimethoxy docetaxel or 4-acetoxy-2α-benzoyloxy-5 ,20-epoxy-1-hydroxy-7 ,10 -dimethoxy-9-oxotaxa-11-en-13α-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenyl propinate (compound A), and to provide its manufacturing method.SOLUTION: There are provided an anhydride, a solvate and an ethanol hetero solvate and a hydrate of dimethoxy docetaxel or compound (A) having PXRD (powder X-ray analysis) diagram showing characteristic lines located at 7.3, 8.1, 9.8, 10.4, 11.1, 12.7, 13.1, 14.3, 15.4 and 15.9±0.2 degree 2 , and further its manufacturing method.
Bibliography:Application Number: JP20130265282