METHOD FOR PRODUCING α-FLUOROACRYLATE ESTER

PROBLEM TO BE SOLVED: To provide a method for producing an α-fluoroacrylate ester capable of obtaining a high raw material conversion rate, high selectivity and a high yield.SOLUTION: There is provided a method for producing a compound represented by formula (1) [where, R represents an alkyl group w...

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Bibliographic Details
Main Authors OTSUKA TATSUYA, GOTO AKIHIRO, YAMAMOTO SADAHIRO, ISHIHARA SUMI, KISHIKAWA YOSUKE, YAMAMOTO AKINORI, KUROKI MASACHIKA, KOMATSU YUZO
Format Patent
LanguageEnglish
Published 10.04.2014
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:PROBLEM TO BE SOLVED: To provide a method for producing an α-fluoroacrylate ester capable of obtaining a high raw material conversion rate, high selectivity and a high yield.SOLUTION: There is provided a method for producing a compound represented by formula (1) [where, R represents an alkyl group which may be replaced by one or more fluorine atoms], the method including a step A of reacting a compound represented by the formula (2), an alcohol represented by formula (3) and carbon monoxide in the presence of a transition metal catalyst and a base to obtain a compound represented by the formula (1). [where, x represents a bromine atom or chlorine atom.] R-OH(3):(where, symbols in the formula represent the same meaning as above.] The transition metal catalyst is a palladium catalyst, the base includes an amine and an inorganic salt, and the reaction is carried out at 60 to 120°C.
Bibliography:Application Number: JP20130180675