COVALENT DIABODY AND USAGE THEREOF

PROBLEM TO BE SOLVED: To provide diabody molecules which can be utilized in the treatment of a variety of diseases and disorders, including immunological disorders, infectious disease, intoxication and cancers.SOLUTION: The diabody molecule comprise a first polypeptide chain and a second polypeptide...

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Bibliographic Details
Main Authors JOHNSON LESLIE S, HUANG LING
Format Patent
LanguageEnglish
Published 30.01.2014
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:PROBLEM TO BE SOLVED: To provide diabody molecules which can be utilized in the treatment of a variety of diseases and disorders, including immunological disorders, infectious disease, intoxication and cancers.SOLUTION: The diabody molecule comprise a first polypeptide chain and a second polypeptide chain. The polypeptide chains are capable of binding epitopes of antigens. The antigens may be from the same or different molecules. The individual polypeptide chains are covalently bound through non-peptide bond covalent bonds, such as, but not limited to, disulfide bonding of cysteine residues located within each polypeptide chain. In particular embodiments, the diabody molecule further comprise an Fc region, which allows antibody-like functionality to be engineered into the molecule.
Bibliography:Application Number: JP20130159568