IL-17A/F HETERODIMERIC POLYPEPTIDE AND THERAPEUTIC USE THEREOF

• Main Authors: LEE JAMES M, GURNEY AUSTIN L, STAROVASNIK MELISSA A, OUYANG WENJUN, HYMOWITZ SARAH, HASS PHILIP E, ARNOTT DAVID P, BALAZS MERCEDESZ, GHILARDI NICO, WU YAN
• Format: Patent
• Language: English
• Published: 19.12.2013
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide IL-17 A/F heterodimeric polypeptides and therapeutic uses thereof.SOLUTION: The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17 A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides and methods for producing the polypeptides. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.