ANTIBODY COMPOSITION

• Main Authors: HANAI NOBUO, KANDA YUTAKA, YAMAZAKI MOTOO, NAKAMURA KAZUYASU, SATO MITSUO, SHINKAWA TOYOHIDE, YAMANE NAOKO, UCHIDA KAZUHISA, YAMANO KAZUYA, HOSAKA EMI
• Format: Patent
• Language: English
• Published: 14.11.2013
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide: a host cell which produces an antibody composition and can control a sugar chain structure bound to an antibody molecule; a cell which can produce an antibody composition having high ADCC activity; a production method of an antibody composition using the cell; and an antibody composition produced by the production method.SOLUTION: An antibody composition contains an antibody to which complex N-glycoside-linked sugar chains are bound and which recognizes GM2, wherein all antibodies have complex N-glycoside-linked sugar chains in which fucose is not bound to N-acetylglucosamine in a reducing terminal.