BORDETELLA PARAPERTUSSIS WHOLE-CELL VACCINE COMPOSITION

PROBLEM TO BE SOLVED: To provide a whole cell bacteria vaccine composition for preventing pertussis originated from Bordetella parapertussis, which contains a whole cell of Bordetella parapertussis, a homogenate of the whole cell or a cell lysate, as an immunogen, and to provide a production method...

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Bibliographic Details
Main Authors KOMATSU EIJI, WATANABE MINEO
Format Patent
LanguageEnglish
Published 24.10.2013
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide a whole cell bacteria vaccine composition for preventing pertussis originated from Bordetella parapertussis, which contains a whole cell of Bordetella parapertussis, a homogenate of the whole cell or a cell lysate, as an immunogen, and to provide a production method thereof.SOLUTION: Bordetella parapertussis is cultured under the conditions of 37°C and three days, and thereafter inactivated by adjusting the cell concentration to 10cells/mL and adding a formaldehyde solution such that the final concentration of formalin is 0.2%. The cell is adjusted to 10cells/mL in terms of cell density by adding sterile phosphate-buffered saline, to give a vaccine composition.
Bibliography:Application Number: JP20130135175