PHOSPHONATE AND PHOSPHINATE COMPOUND AS GLUCOKINASE ACTIVATOR

• Main Authors: SULSKY RICHARD B, TINO JOSEPH A, CHENG PETER T W, SHI YAN, ZHANG HAO, BOLTON SCOTT A, CHEN SEAN S, RYONO DENNIS E, MENG WEI
• Format: Patent
• Language: English
• Published: 24.01.2013
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide compounds which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases.SOLUTION: A phosphonate compound and a phosphinate compound have a structure of formula (I) [wherein Ris a heteroaryl group; Ris -(CH)-Z-(CH)-PO(OR)(OR), -(CH)Z-(CH)-PO(OR)R, -(CH)-Z-(CH)-OPO(OR)R, -(CH)Z-(CH)-OPO(R)(R), or -(CH)Z-(CH)-PO(R)(R)]. Also a method for treating diabetes and related diseases employing the compounds is provided.