DUAL VARIABLE DOMAIN IMMUNOGLOBULIN AND USE THEREOF

PROBLEM TO BE SOLVED: To provide engineered multivalent and multispecific binding proteins, methods for making the proteins, and methods for using the proteins in the prevention and/or treatment of acute and chronic inflammatory and other diseases.SOLUTION: The binding protein comprises a polypeptid...

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Bibliographic Details
Main Authors WU CHENGBIN, DIXON RICHARD W, SALFELD JOCHEN G, GHAYUR TARIQ
Format Patent
LanguageEnglish
Published 22.11.2012
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:PROBLEM TO BE SOLVED: To provide engineered multivalent and multispecific binding proteins, methods for making the proteins, and methods for using the proteins in the prevention and/or treatment of acute and chronic inflammatory and other diseases.SOLUTION: The binding protein comprises a polypeptide chain, wherein the polypeptide chain comprises VD1-(X1)-VD2-C-(X2), wherein VD1 is a first variable domain, VD2 is a second variable domain, C is a constant domain, X1 represents an amino acid or polypeptide, X2 represents an Fc region and n is 0 or 1.
Bibliography:Application Number: JP20120116896