HETEROCYCLIC DERIVATIVES AND THEIR USE AS MEDIATORS OF STEAROYL-CoA DESATURASE

• Main Authors: SUN SHAOYI, SEID BAGHERZADEH MEHRAN, CHAKKA NAGASREE, KODUMURU VISHNUMURTHY, CHOWDHURY SULTAN, KAMBOJ RAJENDER, SVIRIDOV SERGUEI, RAINA VANDNA, LIU SHIFENG, FU JIAN-MIN, ZHANG ZAIHUI, HOU DUANJIE
• Format: Patent
• Language: English
• Published: 20.09.2012
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase.SOLUTION: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I). In the formula (I), x, y, G, J, L, M, V, W, R, R, R, R, R, R, R, R, R, R, and Rare defined in specification. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.