HETEROCYCLIC DERIVATIVES AND THEIR USE AS MEDIATORS OF STEAROYL-CoA DESATURASE

PROBLEM TO BE SOLVED: To provide heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase.SOLUTION: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a...

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Main Authors SUN SHAOYI, SEID BAGHERZADEH MEHRAN, CHAKKA NAGASREE, KODUMURU VISHNUMURTHY, CHOWDHURY SULTAN, KAMBOJ RAJENDER, SVIRIDOV SERGUEI, RAINA VANDNA, LIU SHIFENG, FU JIAN-MIN, ZHANG ZAIHUI, HOU DUANJIE
Format Patent
LanguageEnglish
Published 20.09.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase.SOLUTION: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I). In the formula (I), x, y, G, J, L, M, V, W, R, R, R, R, R, R, R, R, R, R, and Rare defined in specification. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
Bibliography:Application Number: JP20120143296