2,4-DIAMINOPYRIMIDINE COMPOUND HAVING AMINOCYCLOHEXYLALKYL GROUP

PROBLEM TO BE SOLVED: To provide a compound useful as an active ingredient of a pharmaceutical preparation having PKC inhibitory activity, especially of a pharmaceutical composition for inhibiting acute rejection in conducting transplant operations.SOLUTION: The present invention has been completed...

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Bibliographic Details
Main Authors TAKASAGO YUJI, MUKAIYOSHI KOICHIRO, TANAKA AKIRA, SENDA NOBORU, KUNIKAWA SHIGEKI
Format Patent
LanguageEnglish
Published 09.08.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide a compound useful as an active ingredient of a pharmaceutical preparation having PKC inhibitory activity, especially of a pharmaceutical composition for inhibiting acute rejection in conducting transplant operations.SOLUTION: The present invention has been completed through such a process that: compounds having PKC inhibitory activity are studied; as a result, it has been confirmed that: a compound (or a salt thereof ) characterized by having a structure such as aralkyl on the 2-position amino group of 2,4-diaminopyrimidine and also having aminocyclohexylalkyl on the 4-position amino group thereof has excellent PKC inhibitory activity. The 2,4-diaminopyrimidine compound having the aminocyclohexyl alkyl group is usable as a PKC inhibitor, or an acute rejection inhibitor in conducting transplant operations.
Bibliography:Application Number: JP20090121485