9-SUBSTITUTED MINOCYCLINE COMPOUND

• Main Authors: BHATIA BEENA, MCINTYRE LAURA, FRECHETTE ROGER, DUMORNAY JIMMY, ISMAIL MOHAMED, STAPLETON KAREN, NELSON MARK L, RENNIE GLEN, BOWSER TODD, LIU GUI, VISKI PETER, WARCHOL TAD, KOZA DARRELL, VERMA ATUL, HAWKINS PAUL, SHEAHAN PAUL
• Format: Patent
• Language: English
• Published: 07.06.2012
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; DERIVATIVES THEREOF; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

PROBLEM TO BE SOLVED: To provide novel 9-substituted minocycline compounds.SOLUTION: The novel 9-substituted minocycline compound is expressed by the following formula. A region of naphthylthiourea can be various substituents such as phenylurea and phenylsulfone amide. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.