MODIFIED SMALL INTERFERING RNA MOLECULE AND METHOD OF USE

• Main Authors: HOUGHTON MICHAEL, HUANG CHIYUAN
• Format: Patent
• Language: English
• Published: 07.06.2012
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DERIVATIVES THEREOF; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; SUGARS; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide a method for inactivating a hepatitis virus by inhibiting the viral replication in an infected cell using 2'-fluorine dsRNA or siRNA, relating to the field of nucleic acid detection and to the phenomenon of RNA silencing, or RNA interference (RNAi).SOLUTION: The method for inactivating the virus that causes hepatitis in a patient includes (a) s step of administering to the patient a modified double-stranded RNA (dsRNA) or modified short-chain interfering RNA (siRNA) in an effective amount to inactivate the virus and (b) a step of administering to the patient a cholesterol-lowering drug.