MONOCLONAL ANTIBODY BINDING TO hGM-CSF AND MEDICAL COMPOSITION CONTAINING THE SAME

PROBLEM TO BE SOLVED: To disclose an anti-hGM-CSF monoclonal antibody having improved neutralizing capacity to hGM-CSF activity and an antigen-binding fragment of the antibody and to provide a pharmaceutical composition containing the antibody or the antigen-binding fragment.SOLUTION: There are prov...

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Bibliographic Details
Main Authors NAKAJIMA KANTO, PARK JOHN, TAKADA KENZO, KISTLER BARBARA
Format Patent
LanguageEnglish
Published 07.06.2012
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:PROBLEM TO BE SOLVED: To disclose an anti-hGM-CSF monoclonal antibody having improved neutralizing capacity to hGM-CSF activity and an antigen-binding fragment of the antibody and to provide a pharmaceutical composition containing the antibody or the antigen-binding fragment.SOLUTION: There are provided the isolated anti-hGM-CSF monoclonal antibody binding to an epitope of hGM-CSF (sequence No.1) containing ELYK (sequence No.2) and TMMASHYKQH (sequence No.3) or its antigen-binding fragment, and a pharmaceutical composition containing the antibody or the fragment.
Bibliography:Application Number: JP20120006807