COMPOSITION AND METHOD FOR TREATING GLOMERULONEPHRITIS AND OTHER INFLAMMATORY DISEASES

• Main Authors: SQUINTO STEPHEN P, NYE STEVEN H, EVANS MARK J, MATIS LOUIS, WANG YI, THOMAS THOMAS C, SPRINGHORN JEREMY P, ROLLINS SCOTT, WILKINS JAMES A, MUELLER EILEEN ELLIOTT, ROTHER RUSSELL P
• Format: Patent
• Language: English
• Published: 24.05.2012
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; CARE OF BIRDS, FISHES, INSECTS; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DERIVATIVES THEREOF; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NEW BREEDS OF ANIMALS; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; SUGARS; TESTING; TRAPPING; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide a new approach for reducing glomerular inflammation and renal dysfunction associated with glomerulonephritis (GN).SOLUTION: There are provided: a nucleic acid molecule comprising a nucleotide sequence encoding scFv polypeptide containing a specific amino acid sequence; a nucleic acid molecule comprising a nucleotide sequence encoding polypeptide containing a specific variable light chain region amino acid sequence corresponding to amino acid 3 to amino acid 110; a nucleic acid molecule comprising a nucleotide sequence encoding polypeptide containing a specific variable heavy chain region amino acid sequence corresponding to amino acid 1 to amino acid 122; or an isolated protein comprising (a) a first polypeptide region containing a specific variable light chain region amino acid sequence corresponding to amino acid 3 to amino acid 110 and (b) a second polypeptide region containing a specific variable heavy chain region amino acid sequence corresponding to amino acid 1 to amino acid 122.