PRODUCTION METHOD OF CYCLIC AMINOBENZOIC ACID ESTER DERIVATIVE

PROBLEM TO BE SOLVED: To provide a production method of a cyclic amino benzoic acid derivative which is an excellent agonist of a human peroxiosome proliferative-agent receptor (PPAR), is high in efficiency and suitable for industrial production.SOLUTION: The two-nitro benzoic acid ester derivative...

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Main Authors NOMURA MASAHIRO, SAKAMOTO NOBUTAKA, KOBAYASHI KENICHI, YUMOTO KAZUHIRO, TAKANO YASUO, KANAZAWA SHINTARO, TSUBUKI TAKESHI
Format Patent
LanguageEnglish
Published 15.03.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide a production method of a cyclic amino benzoic acid derivative which is an excellent agonist of a human peroxiosome proliferative-agent receptor (PPAR), is high in efficiency and suitable for industrial production.SOLUTION: The two-nitro benzoic acid ester derivative and a piperidine derivative are made to react with each other, and after reducing a nitro group of an obtained compound, a deamination reaction is performed by using a nitrous acid or its salt and a reducer. Thus, the cyclic aminobenzoic acid derivative being the PPARα agonist and its hydrate are produced.
Bibliography:Application Number: JP20080329224