PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITOR OF GLYCOGEN PHOSPHORYLASE

PROBLEM TO BE SOLVED: To provide a novel glycogen phosphorylase inhibitor.SOLUTION: Compounds represented by Formula (I), or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hyp...

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Main Authors BRADLEY STUART EDWARD, PROCTER MARTIN JAMES, MURRAY PETER JOHN, SAMBROOK SMITH COLIN PETER, ROWLEY ROBERT JOHN, THOMAS GERARD HUGH, SCHOFIELD KAREN LESLEY, KRULLE THOMAS MARTIN
Format Patent
LanguageEnglish
Published 15.12.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide a novel glycogen phosphorylase inhibitor.SOLUTION: Compounds represented by Formula (I), or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.
Bibliography:Application Number: JP20110174163