FORMULATION OF SUBEROYLANILIDE HYDROXAMIC ACID AND METHOD FOR PRODUCING SAME

PROBLEM TO BE SOLVED: To provide a pharmaceutical composition with a specific dissolution profile which comprises suberoylanilide hydroxamic acid or a pharmaceutically acceptable salt or hydrate thereof as an active ingredient.SOLUTION: There is provided a pharmaceutical composition comprising suber...

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Main Authors SELL BRIAN, STARBUCK CINDY, REED ROBERT A, COHEN BENJAMIN MAX, WONG JEANNIE CHOW, DIENEMANN ERIK A, GALLACHER KIMBERLY, CAPODANNO VINCENT R, MILLER THOMAS A, COTE AARON S, TUNG HSIEN-HSIN, RAJNIAK PAVOL, MOSER JUSTIN, WANG QINGXI, IKEDA CRAIG
Format Patent
LanguageEnglish
Published 15.12.2011
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide a pharmaceutical composition with a specific dissolution profile which comprises suberoylanilide hydroxamic acid or a pharmaceutically acceptable salt or hydrate thereof as an active ingredient.SOLUTION: There is provided a pharmaceutical composition comprising suberoylanilide hydroxamic acid or a pharmaceutically acceptable salts or hydrate thereof as an active ingredient, in which the entire active ingredient of the pharmaceutical composition is 43-63% dissolved at 10 minutes, 66-86% dissolved at 30 minutes, and 77-97% dissolved at 60 minutes in vitro.
Bibliography:Application Number: JP20110157930