HETEROCYCLIC INHIBITOR OF MEK AND METHOD OF USE THEREOF
PROBLEM TO BE SOLVED: To provide medicaments useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. SOLUTION: There are provided compounds of formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8and R9, W, X and Y a...
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Language | English |
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08.09.2011
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Abstract | PROBLEM TO BE SOLVED: To provide medicaments useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. SOLUTION: There are provided compounds of formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8and R9, W, X and Y are as defined in the specification, wherein X is N or CR10, Y is NR3, O, S, S(O), S(O)2, C(O) or CH2, R1, R2R8, R9and R10are independently, hydrogen, hydroxy, halogen, or others. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds are also provided. COPYRIGHT: (C)2011,JPO&INPIT |
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AbstractList | PROBLEM TO BE SOLVED: To provide medicaments useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. SOLUTION: There are provided compounds of formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8and R9, W, X and Y are as defined in the specification, wherein X is N or CR10, Y is NR3, O, S, S(O), S(O)2, C(O) or CH2, R1, R2R8, R9and R10are independently, hydrogen, hydroxy, halogen, or others. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds are also provided. COPYRIGHT: (C)2011,JPO&INPIT |
Author | WALLACE ELI SEO JEONGBEOB LYSSIKATOS JOSEPH P BLAKE JIM MARLOW ALLISON L YANG HONG WOON |
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Snippet | PROBLEM TO BE SOLVED: To provide medicaments useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. SOLUTION:... |
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SubjectTerms | AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY FISHING FORESTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TRAPPING |
Title | HETEROCYCLIC INHIBITOR OF MEK AND METHOD OF USE THEREOF |
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