PRODRUG OF 9-AMINOMETHYL TETRACYCLINE COMPOUND

PROBLEM TO BE SOLVED: To provide a prodrug of a 9-aminomethyl-substituted tetracycline compound, to provide a method for using the compound, and to provide a pharmaceutical composition containing the same. SOLUTION: The prodrug of the 9-aminomethyl-substituted tetracycline compound is represented by...

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Main Authors BHATIA BEENA, PAN JINGWEN, HONEYMAN LAURA, KIM OAK, BERNIAC JOEL, MECHICHE RACHID, AMOO VICTOR, GRIER MARK, KWASI OHEMENG, ASSEFA HAREGEWEIN, BOWSER TODD, CHEN JACKSON
Format Patent
LanguageEnglish
Published 03.03.2011
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide a prodrug of a 9-aminomethyl-substituted tetracycline compound, to provide a method for using the compound, and to provide a pharmaceutical composition containing the same. SOLUTION: The prodrug of the 9-aminomethyl-substituted tetracycline compound is represented by, e.g. formula (I) (wherein, E is oxygen, nitrogen, or a covalent bond; and G is alkyl; heterocyclic alkyl; aryl; alkylcarbonyloxyalkyl; arylcarbonyloxyalkyl; alkyloxycarbonyloxyalkyl; arylalkylcarbonyloxyalkyl; alkyloxyalkylcarbonyloxyalkyl; or alkoxyalkoxycarbonyloxyalkyl). COPYRIGHT: (C)2011,JPO&INPIT
Bibliography:Application Number: JP20100229213