METHOD FOR PRODUCING OPTICALLY ACTIVE tert-LEUCINE

PROBLEM TO BE SOLVED: To provide an industrially practicable method having excellent operability for producing optically active L-or D-tert-leucine important as a raw material for medicines and agrochemicals. SOLUTION: In a method for making a biocatalyst for stereoselectively hydrolyzing tert-leuci...

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Bibliographic Details
Main Authors IIDA SHIN, ARIE SACHIKO, SUGITA MASANORI
Format Patent
LanguageEnglish
Published 24.12.2010
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
SPIRITS
VINEGAR
WINE
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Summary:PROBLEM TO BE SOLVED: To provide an industrially practicable method having excellent operability for producing optically active L-or D-tert-leucine important as a raw material for medicines and agrochemicals. SOLUTION: In a method for making a biocatalyst for stereoselectively hydrolyzing tert-leucine amide act on tert-leucine amide and then substituting a solvent of a reaction solution of the biocatalyst from a water system to a poor solvent system of optically active tert-leucine so as to crystallize, precipitate and collect formed optically active tert-leucine, the solution to be supplied to the solvent substitution contains an acetate radical and an alcohol is used as a poor solvent when substituted with a poor solvent system. COPYRIGHT: (C)2011,JPO&INPIT
Bibliography:Application Number: JP20090140195