TREATMENT OF TNFalpha RELATED DISORDER
PROBLEM TO BE SOLVED: To provide a method of treating TNFα (tumor necrosis factor) related disorders using a TNFα inhibitor such as a TNFα antibody. SOLUTION: The method includes dissociating an isolated human antibody or an antigen binding portion thereof from the human TNFα at a Kd of 1×10-8M or l...
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Main Authors | , , , , , , , , , , |
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Format | Patent |
Language | English |
Published |
24.09.2010
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Subjects | |
Online Access | Get full text |
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Summary: | PROBLEM TO BE SOLVED: To provide a method of treating TNFα (tumor necrosis factor) related disorders using a TNFα inhibitor such as a TNFα antibody. SOLUTION: The method includes dissociating an isolated human antibody or an antigen binding portion thereof from the human TNFα at a Kd of 1×10-8M or less and a Koff velocity constant of 1×10-3s-1 or less measured by surface plasmon resonance, and neutralizing human TNFα cytotoxicity with the human antibody or the antigen binding portion thereof at an IC50 of 1×10-7M or less in a standard in vitro L929 assay. COPYRIGHT: (C)2010,JPO&INPIT |
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Bibliography: | Application Number: JP20100057713 |