METHOD FOR ASSESSMENT OF ONSET RISK OF UROTHELIAL CARCINOMA USING BAC CLONE, AND METHOD FOR PREDICTING PROGNOSIS OF THE RISK

• Main Authors: ARAI SHIGESATO, INASAWA JOJI, KANAI YAE, NISHIYAMA NAOTAKA
• Format: Patent
• Language: English
• Published: 24.09.2010
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide new methods for determining the risk of onset of urothelial carcinoma and prognostic defect risk, or recurrence risk in bladder of renal pelvis-ureteral cancer. SOLUTION: The methods includes the steps of: (a) preparing urothelial-derived genomic DNA of a relevant subject; (b) examining the presence/absence of a DNA methylation in an urothelial carcinoma onset-associated region, urothelial carcinoma prognosis-associated, or renal pelvis-ureteral cancer prognosis prognosis-associated region, as for the genomic DNA prepared in the step (a); and (c) determining whether the subject is classified as a carcinogenesis high-risk group, prognosis defect group, or in-bladder recurrence high-risk group, based on a DNA methylation pattern clarified in the step (b). COPYRIGHT: (C)2010,JPO&INPIT