PREPARATION OF PHARMACEUTICAL SALTS OF 4[(Z)-(4-BROMOPHENYL)(ETHOXYIMINO)METHYL]-1'-[(2,4-DIMETHYL-1-OXIDO-3-PYRIDINYL)CARBONYL]-4'-METHYL-1,4'BIPIPERIDINE AS CCR5-ANTAGONIST FOR TREATMENT OF AIDS AND RELATED HIV INFECTION

PROBLEM TO BE SOLVED: To prepare a pharmaceutically useful salt useful for treating AIDS and related HIV infections. SOLUTION: There is provided a method for preparing a mixture of rotamers or rotamer pairs of a salt of a basic compound of formula (I), wherein the mixture comprises one or more rotam...

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Bibliographic Details
Main Authors CHEN MINZHANG, D'SA BOSCO, LEONG WILLIAM W, TANG SUHAN
Format Patent
LanguageEnglish
Published 12.08.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To prepare a pharmaceutically useful salt useful for treating AIDS and related HIV infections. SOLUTION: There is provided a method for preparing a mixture of rotamers or rotamer pairs of a salt of a basic compound of formula (I), wherein the mixture comprises one or more rotamers or rotamer pairs of the salt in a higher molar percentage than the corresponding rotamers or rotamer pairs of the salt, and wherein the method comprising reacting the basic compound with an acid in a mixture with a solvent. COPYRIGHT: (C)2010,JPO&INPIT
Bibliography:Application Number: JP20100047165