METHOD FOR PRODUCING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE AND PRODUCTION INTERMEDIATE OF THE SAME

PROBLEM TO BE SOLVED: To provide an efficient production method of an aminoacetylpyrrolidinecarbonitrile derivative useful as a DPP-IV inhibitor. SOLUTION: The production method of the aminoacetylpyrrolidinecarbonitrile derivative represented by formula 4 comprises causing a bicycloester derivative...

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Bibliographic Details
Main Author KANAZAWA SHINTARO
Format Patent
LanguageEnglish
Published 02.04.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide an efficient production method of an aminoacetylpyrrolidinecarbonitrile derivative useful as a DPP-IV inhibitor. SOLUTION: The production method of the aminoacetylpyrrolidinecarbonitrile derivative represented by formula 4 comprises causing a bicycloester derivative or a salt thereof to react with a sulfonyloxyacetylpyrrolidinecarboxamide derivative to obtain an aminoacetylpyrrolidinecarboxamide derivative-sulfonic acid salt and causing a dehydrating agent to act on the obtained salt. COPYRIGHT: (C)2010,JPO&INPIT
Bibliography:Application Number: JP20080235977