INHIBITING RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREA

• Main Authors: PAULSEN HOLGER, LEE WENDY, KHIRE UDAY, RIEDL BERND, SMITH ROGER A, WOOD JILL E, REDMAN ANIKO, LOWINGER TIMOTHY BRUNO, DUMAS JACQUES, HATOUM-MOKDAD HOLIA, JOHNSON JEFFREY, SCOTT WILLIAM J
• Format: Patent
• Language: English
• Published: 25.03.2010
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide a heterocyclic urea compound having an activity of inhibiting RAF kinase. SOLUTION: The urea compound is represented by formula I: A-NH-CO-NH-B. In the formula, A represents a thienyl group having a substituent, a furyl group, a pyrazolyl group, an isoxazolyl group, a thiadiazolyl group or the like; and B in general represents a substituted or unsubstituted ≤30C aryl or heterocyclic aryl segment of up to a tricycle having at least 5 to 6 aromatic structures containing 0 to 4 member(s) selected from the group consisting of nitrogen, oxygen, and sulfur. COPYRIGHT: (C)2010,JPO&INPIT