INHIBITING RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREA

• Main Authors: PAULSEN HOLGER, LEE WENDY, KHIRE UDAY, RIEDL BERND, SMITH ROGER A, WOOD JILL E, REDMAN ANIKO, LOWINGER TIMOTHY BRUNO, DUMAS JACQUES, HATOUM-MOKDAD HOLIA, JOHNSON JEFFREY, SCOTT WILLIAM J
• Format: Patent
• Language: English
• Published: 25.03.2010
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide an isooxazolyl urea compound having an activity of inhibiting RAF kinase, useful in treating solid cancer, for example a cancerous tumor [such as a cancerous tumor of a lung, spleen, thyroid, bladder, or colon, or a disease of bone marrow (bone marrow leukemia for example)], or an adenoma (a villus-like colon adenoma, for example), or the like. SOLUTION: The compound is represented by the following formula (in the formula, R1 is selected from the group consisting of 3-10C alkyl, 3-10C cycloalkyl, 3-10C halosubstituted alkyl up to perhaloalkyl and 3-10C halosubstituted cycloalkyl up to perhalocycloalkyl, and B represents phenyl, phenyl substituted with pyridyl or -Y-Ar, pyridinyl, indolinyl, isoquinolinyl, quinolinyl or naphthyl). COPYRIGHT: (C)2010,JPO&INPIT