METHOD FOR PREPARATION OF OPTICALLY ACTIVE MUSCOL

PROBLEM TO BE SOLVED: To provide a useful production method for synthesizing four optical isomers of muscol and determining absolute configuration thereof, a perfume useful for perfume industry by judging the fragrance of the optical isomers and further a new perfume composition and cosmetic having...

Full description

Saved in:
Bibliographic Details
Main Authors IWAI HISAO, HIRAI SANKICHI, YUASA YOSHIFUMI, KOMAKI RYOICHI, OSHIKUBO SHIGEMASA
Format Patent
LanguageEnglish
Published 04.02.2010
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
SPIRITS
VINEGAR
WINE
Online AccessGet full text

Cover

More Information
Summary:PROBLEM TO BE SOLVED: To provide a useful production method for synthesizing four optical isomers of muscol and determining absolute configuration thereof, a perfume useful for perfume industry by judging the fragrance of the optical isomers and further a new perfume composition and cosmetic having excellent fragrance. SOLUTION: The method for producing (1R, 3R)-muscol and (1S, 3S)-muscol is characterized by including a process of reducing a (±)-muscone with an alkali metal salt of tri-secondary-butylborohydride to prepare a (±)-tans-muscol, a process of asymmetric esterification of the resultant (±)-trans-muscol by acting an acylating reagent and a hydrolase to prepare an acylated (1R, 3R)-muscol and (1S, 3S)-muscol, and a process of hydrolyzing the acylated compound with an acid or an alkali. COPYRIGHT: (C)2010,JPO&INPIT
Bibliography:Application Number: JP20090253213