NEW PEPTIDE AS NS3-SERINE PROTEASE INHIBITOR OF HEPATITIS C VIRUS

• Main Authors: PINTO PATRICK A, ARASAPPAN ASHOK, MCCORMICK JINPING L, WANG HAIYAN, GANGULY ASHIT K, VACCARO HENRY A, BOGEN STEPHANE L, ZHU ZHAONING, SCOTT JEFFREY KEMP, TAMURA SUSAN Y, CHAN TIN-YAU, SAKSENA ANIL K, NJOROGE F GEORGE, BENNETT FRANK, JAO EDWIN E, SANTHANAM BAMA, VENKATRAMAN SRIKANTH, PAREKH TEJAL N, GIRIJAVALLABHAN VIYYOOR MOOPIL, PIKE RUSSELL E, LOVEY RAYMOND G, LIM-WILBY MARGUERITA, ODILE ESTHER LEVY, CHEN KEVIN X, LIU YI-TSUNG
• Format: Patent
• Language: English
• Published: 17.12.2009
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide a new peptide compound having HCV protease inhibition activity and a method for producing the compound, in addition, a pharmaceutical composition containing the compound and a method for using them in treating diseases associated with HCV proteases. SOLUTION: A new class of HCV protease inhibitors, a pharmaceutical composition containing one or more kinds of the compounds, a method for producing the pharmaceutical composition containing one or more kinds of the compounds, a method for treating, preventing or improving one or more symptoms of hepatitis C, a method for controlling the interaction between HCV polypeptides and HCV proteases, a compound inhibiting HCV NS3/NS4a serine protease activity and a peptide compound including an amino acid sequence from P3 to P2' are disclosed. COPYRIGHT: (C)2010,JPO&INPIT