COATED PARTICULATE CONTAINING PROTON PUMP INHIBITOR

PROBLEM TO BE SOLVED: To provide a coated particulate for an orally disintegrating tablet containing a benzimidazole proton pump inhibitor, which has good drug release characteristics and can be produced with a good yield, and to provide an orally disintegrating tablet of a benzimidazole proton pump...

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Bibliographic Details
Main Authors UETSUKI KENJI, KANAI KYOHEI, HIZAKI MASAYA
Format Patent
LanguageEnglish
Published 05.11.2009
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide a coated particulate for an orally disintegrating tablet containing a benzimidazole proton pump inhibitor, which has good drug release characteristics and can be produced with a good yield, and to provide an orally disintegrating tablet of a benzimidazole proton pump inhibitor having good storage stability. SOLUTION: The coated particulate is obtained by coating a drug layer containing a benzimidazole proton pump inhibitor and a crospovidone fine powder having an average particle size of 3-10 μm on a spherical crystalline cellulose particle and then coating an inert interlayer and an enteric coating layer. The orally disintegrating tablet includes the coated particulate. COPYRIGHT: (C)2010,JPO&INPIT
Bibliography:Application Number: JP20090074466