METHOD AND MATERIAL FOR DETECTING SEPSIS AND SEPSIS-LIKE SYSTEMIC INFECTION

• Main Authors: STRUCK JOACHIM, BERGMANN ANDREAS, WEGLOEHNER WOLFGANG
• Format: Patent
• Language: English
• Published: 15.10.2009
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

PROBLEM TO BE SOLVED: To solve the problem that procalcitonin formed in the case of sepsis is provisionally and generally regarded as the same as a calcitonin precursor, therefore, a peptide (procalcitonin 1-116) having a known procalcitonin sequence of 116 amino acids, as analysis assay methods have not clarified the difference between known procalcitonin as the calcitonin precursor and procalcitonin formed in the case of sepsis. SOLUTION: Recombinant procalcitonin 3-116 can be used for diagnosis and treatment of sepsis and as a marker in measuring prohormones except procalcitonin and dipeptidyl peptidase IV, as well as in diagnosing sepsis. COPYRIGHT: (C)2010,JPO&INPIT