GENE DISRUPTION, COMPOSITION, AND METHOD RELATING THERETO

• Main Authors: STALA JOY, VOGEL PETER, YEH JUNG-HUA, MASSEY ERIN MARIE, PETERSON ANDREW, QIAN NI NANCY, DESAUVAGE FREDERIC, KETCHERSIDE LORELEI DIANE, HORNER ALLISON ANNE BYERS, SCHRICK JEFFREY J, COMBS KATHERIN E, MONTGOMERY CHARLES A, EDWARDS JOEL, SHI ZHENG-ZHENG, YE WEILAN, CLARKE CATHERINE ANNE B, GRANT DEANNA, VIATOR COLLEEN M, HUANG WENHU, SPARKS MARY JEAN, GODOWSKI PAUL, PAYNE BOBBY JOE, DING ZHIYONG
• Format: Patent
• Language: English
• Published: 30.07.2009
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; CARE OF BIRDS, FISHES, INSECTS; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NEW BREEDS OF ANIMALS; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; TRAPPING; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide gene disruptions, compositions, and method relating thereto. SOLUTION: A transgenic animals, as well as compositions and methods relating to the characterization of gene function are disclosed. Specifically, a transgenic mice comprises disruptions in genes described in the specification. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities. COPYRIGHT: (C)2009,JPO&INPIT