PHARMACEUTICAL COMPOSITION OF 5,7,14-TRIAZATETRACYCLO[10.3.1.02,11.04,9]-HEXADECA-2(11), 3,5,7,9-PENTAENE

• Main Authors: ROY MICHAEL CHRISTOPHER, MOSES SARA KRISTEN, QUAN ERNEST SHING, WATERMAN KENNETH CRAIG, SMITH SCOTT WENDELL, AM ENDE MARY TANYA
• Format: Patent
• Language: English
• Published: 21.05.2009
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide controlled-release (CR) oral pharmaceutical dosage forms of 5,8,14-triazatetracyclo[10.3.1.02,11. 04,9]-hexadeca-2(11), 3,5,7,9-pentaene or their pharmaceutically acceptable salts; and to provide methods of using them to reduce nicotine addiction or aiding in the cessation or lessening of smoking while reducing nausea as an adverse effect. SOLUTION: The controlled-release dosage forms are suitable for administration to a subject, involving a means for administering the compounds or their salts to the subject at a rate of 0.1-1 mgA/hour. Where, the means involves a coated tablet, a matrix tablet, multi-particles or coated multi-particles. COPYRIGHT: (C)2009,JPO&INPIT