2-ARYL-BENZIMIDAZOLE-5-CARBOXAMIDE DERIVATIVE

PROBLEM TO BE SOLVED: To provide a 2-aryl-benzimidazole derivative which can inhibit an sEH (soluble epoxide hydrolase) activity to increase EETs (epoxyeicosatrienoic acids) and is expected as a medicine for circulatory organ diseases including hypertension, cerebral infarction, and renal diseases,...

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Main Authors OTA TOMOKI, BUSUJIMA TAKESHI, HIRANO HITOMI, KAKINUMA HIROYUKI
Format Patent
LanguageEnglish
Published 08.01.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide a 2-aryl-benzimidazole derivative which can inhibit an sEH (soluble epoxide hydrolase) activity to increase EETs (epoxyeicosatrienoic acids) and is expected as a medicine for circulatory organ diseases including hypertension, cerebral infarction, and renal diseases, based on a vasodilator action, a series of inflammatory diseases via an NFκB/IκB kinase activation, autoimmune diseases, endocrine metabolic diseases including hyperlipemia and diabetes, and adult respiratory distress syndromes. SOLUTION: This compound is a 2-aryl-benzimidazole derivative represented by formula of Fig. a pharmaceutically acceptable salt or its hydrate. COPYRIGHT: (C)2009,JPO&INPIT
Bibliography:Application Number: JP20050299464