REACTION REAGENT FOR TRIFLUOROMETHYLATION

PROBLEM TO BE SOLVED: To provide a highly versatile and efficient reaction reagent for trifluoromethylation. SOLUTION: The reaction reagent for trifluoromethylation comprises an iron compound, trifluoromethyl iodide, a sulfoxide and a peroxide. The reaction reagent may contain an acid in addition to...

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Bibliographic Details
Main Authors TOKUHISA KENJI, YAMAMOTO KIYOUKO, YAMAKAWA SATORU, URAKUCHI DAISUKE
Format Patent
LanguageEnglish
Published 19.06.2008
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:PROBLEM TO BE SOLVED: To provide a highly versatile and efficient reaction reagent for trifluoromethylation. SOLUTION: The reaction reagent for trifluoromethylation comprises an iron compound, trifluoromethyl iodide, a sulfoxide and a peroxide. The reaction reagent may contain an acid in addition to the ingredients. For example, the iron compound may be iron (II) sulfate, ammonium iron (II) sulfate, iron (II) tetrafluoroborate, ferrocene, bis(η5-pentamethylcyclopentadienyl)iron or an iron powder. The sulfoxide may be dimethylsulfoxide. The peroxide may be hydrogen peroxide or a hydrogen peroxide-urea complex. The acid may be sulfuric acid, tetrafluoroboric acid or trifluoromethanesulfonic acid. COPYRIGHT: (C)2008,JPO&INPIT
Bibliography:Application Number: JP20070288135