PROCESSES FOR PREPARATION OF 7-ALPHA-CARBOXYL-9,11-EPOXY STEROID COMPOUND AND INTERMEDIATE USEFUL THEREIN AND GENERAL PROCESS FOR EPOXIDATION OF OLEFINIC DOUBLE BOND

• Main Authors: MUCCIARIELLO GENNARO, KUNDA SASTRY A, BAEZ JULIO A, WIECZOREK JOSEPH, POZZO MARK J, WANG PING T, LIU CHIN, SING YUEN-LUNG L, ERB DERNHARD, NG JOHN S, ANDERSON DENNIS K, VANZANELLA FORTUNATO, LETENDRE LEO J, LAWSON JON P
• Format: Patent
• Language: English
• Published: 01.05.2008
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; STEROIDS; VINEGAR; WINE

PROBLEM TO BE SOLVED: To synthesize epoxymexrenone and an epoxymexrenone-based compound. SOLUTION: Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone compounds of the formula I, wherein: -A-A- represents the group -CHR4-CHR5- or -CR4=CR5-; R3is independently selected from proper substituents; R1represents an alpha-oriented lower alkoxycarbonyl or hydroxycarbonyl group; -B-B- represents the group -CHR6-CHR7- or an alpha- or beta- oriented group; R8and R9are each independently selected from proper substituents, or together comprise a carbocyclic or heterocyclic ring structure, or R8or R9together with R7comprise a carbocyclic or heterocyclic ring structure fused to the pentacyclic D ring. COPYRIGHT: (C)2008,JPO&INPIT