DETECTION OF DNA SEQUENCE VARIATION
PROBLEM TO BE SOLVED: To provide a common method applicable to all variants generally used as a DNA marker for genetic analysis. SOLUTION: The analysis method comprises preparing a polynucleotide target involving nucleotide of variable base and one oligonucleotide probe fixed on a support which prob...
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Format | Patent |
Language | English |
Published |
29.11.2007
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Abstract | PROBLEM TO BE SOLVED: To provide a common method applicable to all variants generally used as a DNA marker for genetic analysis. SOLUTION: The analysis method comprises preparing a polynucleotide target involving nucleotide of variable base and one oligonucleotide probe fixed on a support which probe is complementary to the target and terminates at a position before its 5' terminal by one base; and comprises (a) incubating the target with the probe to form a duplex chain, (b) incubating the duplex chain with a labelled oligonucleotide complementary to the target including predicted variant of the target under a ligation condition, and (c) monitoring the addition of oligonucleotide to probe by ligation of the step (b) as one exhibiting point mutation at the specific position in the target. COPYRIGHT: (C)2008,JPO&INPIT |
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AbstractList | PROBLEM TO BE SOLVED: To provide a common method applicable to all variants generally used as a DNA marker for genetic analysis. SOLUTION: The analysis method comprises preparing a polynucleotide target involving nucleotide of variable base and one oligonucleotide probe fixed on a support which probe is complementary to the target and terminates at a position before its 5' terminal by one base; and comprises (a) incubating the target with the probe to form a duplex chain, (b) incubating the duplex chain with a labelled oligonucleotide complementary to the target including predicted variant of the target under a ligation condition, and (c) monitoring the addition of oligonucleotide to probe by ligation of the step (b) as one exhibiting point mutation at the specific position in the target. COPYRIGHT: (C)2008,JPO&INPIT |
Author | SOUTHERN EDWIN MELLOR CASE-GREEN STEPHEN C PRITCHARD CLARE E |
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Snippet | PROBLEM TO BE SOLVED: To provide a common method applicable to all variants generally used as a DNA marker for genetic analysis. SOLUTION: The analysis method... |
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SubjectTerms | BEER BIOCHEMISTRY CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING THEIR RELEVANT APPARATUS TRANSPORTING VINEGAR WINE |
Title | DETECTION OF DNA SEQUENCE VARIATION |
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