METHOD FOR PRODUCING OPTICALLY ACTIVE 2-AMINO-3-(ALKOXY-SUBSTITUTED PHENYL)PROPANOATE DERIVATIVE

PROBLEM TO BE SOLVED: To provide a method for producing an optically active 2-amino-3-(alkoxy-substituted phenyl)propanoate derivative (2) which is an important intermediate in the production of medicines and the like. SOLUTION: This method for producing the optically active 2-amino-3-(alkoxy-substi...

Full description

Saved in:
Bibliographic Details
Main Authors KAWASAKI HIROAKI, TAKEDA TOSHIHIRO
Format Patent
LanguageEnglish
Published 25.10.2007
Subjects
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

More Information
Summary:PROBLEM TO BE SOLVED: To provide a method for producing an optically active 2-amino-3-(alkoxy-substituted phenyl)propanoate derivative (2) which is an important intermediate in the production of medicines and the like. SOLUTION: This method for producing the optically active 2-amino-3-(alkoxy-substituted phenyl)propanoate derivative (2), comprising reacting an optically active 2-amino-3-(hydroxy-substituted phenyl)propanoate derivative (1) with a chlorinated alkyl compound (3) in an organic solvent, is characterized in that a metal halide is made to coexist to prevent lacemization. Thereby, the highly optically pure, optically active 2-amino-3-(alkoxy-substituted phenyl)propanoate derivative (2) can simply, efficiently and stably be produced in an industrial scale. COPYRIGHT: (C)2008,JPO&INPIT
Bibliography:Application Number: JP20060106278