METHOD FOR PRODUCING alpha-GLYCEROPHOSPHORYLCHOLINE CRYSTAL

PROBLEM TO BE SOLVED: To provide a method for producing α-glycerophosphorylcholine crystal by carrying out the hydrolytic ring-opening reaction of a 1,3-dioxolane glycerylphosphorylcholine compound expressed by a specific formula in the presence of a cationic ion-exchange resin. SOLUTION: The method...

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Bibliographic Details
Main Authors KYO YOSHITETSU, KATAOKA SHINGO
Format Patent
LanguageEnglish
Published 18.10.2007
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:PROBLEM TO BE SOLVED: To provide a method for producing α-glycerophosphorylcholine crystal by carrying out the hydrolytic ring-opening reaction of a 1,3-dioxolane glycerylphosphorylcholine compound expressed by a specific formula in the presence of a cationic ion-exchange resin. SOLUTION: The method for the production of α-glycerophosphorylcholine crystal comprises the reaction of a 1,3-dioxolane compound expressed by a specific formula with 2-chloro-2-oxa-1,3,2-dioxaphosphorane expressed by a specific formula and trimethylamine, the hydrolytic ring-opening reaction of the obtained 1,3-dioxolane-glycerylphosphorylcholine compound expressed by a specific formula in a water-containing solvent in the presence of a cationic ion-exchange resin, and the vacuum drying of the product in the presence of an azeotropic solvent with water to effect the crystallization of the compound. COPYRIGHT: (C)2008,JPO&INPIT
Bibliography:Application Number: JP20060095446