REFORMATSKY REAGENT IN STABLE FORM, AND PROCESS FOR PRODUCING THE SAME

• Main Authors: HANDA HISAFUMI, MIKI MASATAKA, NAKAMOTO KOJI, KAWAKAMI JUNICHI, NUWA UTSU
• Format: Patent
• Language: English
• Published: 19.07.2007
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide an industrially advantageous process for producing a steroid C17, 20lyase inhibitor represented by the general formula (I): and to provide a Reformatsky reagent in a stable form suitable for the process. SOLUTION: In the present invention, a compound represented by the general formula (I) (the symbols present specific meanings, respectively) is produced by reducing a specific β-hydroxy ester compound derivative or a salt thereof obtained from a specific carbonyl compound in a Reformatsky reaction in the presence of a metal hydride complex and a metal halide, and then subjecting it to a ring-closing reaction. In the above Reformatsky reaction, it is useful to use a stable solution of a compound represented by the general formula BrZnCH2COOC2H5or a crystal of the compound which is represented by the formula (BrZnCH2COOC2H5-THF)2. COPYRIGHT: (C)2007,JPO&INPIT