REFORMATSKY REAGENT IN STABLE FORM, AND PROCESS FOR PRODUCING THE SAME

PROBLEM TO BE SOLVED: To provide an industrially advantageous process for producing a steroid C17, 20lyase inhibitor represented by the general formula (I): and to provide a Reformatsky reagent in a stable form suitable for the process. SOLUTION: In the present invention, a compound represented by t...

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Bibliographic Details
Main Authors HANDA HISAFUMI, MIKI MASATAKA, NAKAMOTO KOJI, KAWAKAMI JUNICHI, NUWA UTSU
Format Patent
LanguageEnglish
Published 19.07.2007
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide an industrially advantageous process for producing a steroid C17, 20lyase inhibitor represented by the general formula (I): and to provide a Reformatsky reagent in a stable form suitable for the process. SOLUTION: In the present invention, a compound represented by the general formula (I) (the symbols present specific meanings, respectively) is produced by reducing a specific β-hydroxy ester compound derivative or a salt thereof obtained from a specific carbonyl compound in a Reformatsky reaction in the presence of a metal hydride complex and a metal halide, and then subjecting it to a ring-closing reaction. In the above Reformatsky reaction, it is useful to use a stable solution of a compound represented by the general formula BrZnCH2COOC2H5or a crystal of the compound which is represented by the formula (BrZnCH2COOC2H5-THF)2. COPYRIGHT: (C)2007,JPO&INPIT
Bibliography:Application Number: JP20070080801